Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAn amyloidophylic dye that specifically stains stacked β sheet aggregates

General description

An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

An amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Altschuler, S.E., et al. 2012. Biochemistrin press.Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.Fezoui, Y., et al. 2000. Amyloid7, 166.Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.Kramport, M., et al. 2000. Chem. Biol.7, 855.Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

Packaging

500 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

Warning

Toxicity: Standard Handling (A)